Antineutrophil cytoplasmic antibody and vasculitis: much more than a disease marker

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Antineutrophil cytoplasmic antibody and vasculitis: much more than a disease marker.

Many forms of necrotizing small vessel vasculitis manifest glomerulonephritis, pulmonary hemorrhage and cutaneous purpura. Because the histologic appearance of the vasculitic lesions is similar in these conditions, early pathologists and clinicians resorted to categorizing small vessel vasculitides based on vessel size and systemic distribution. Not surprisingly, due to the tremendous overlap i...

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Stress and Disease Onset in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis

Objective To explore the potential contribution of stress as a trigger for disease onset in patients with antineutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV). Methods 53 AAV and 85 rheumatoid arthritis (RA) patients as well as 53 healthy controls (HC) were thoroughly asked for the number and impact of stressful life events, coping strategies, and available social support 12...

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Treatment of antineutrophil cytoplasmic antibody-associated vasculitis.

PURPOSE OF REVIEW The primary idiopathic small-vessel vasculitis syndromes include granulomatosis with polyangiitis, Churg-Strauss syndrome, and microscopic polyangiitis. These disorders are commonly referred to as antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides and prominently affect the pulmonary vasculature. Although significant progress has been made in the management of ...

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Medial medullary infarction caused by antineutrophil cytoplasmic antibody-related vasculitis

RATIONALE Medial medullary infarction accounts for less than 1% of brain infarctions, and medial medullary infarctions is very rarely caused by antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. PATIENT CONCERNS We report the case of a 76-year-old man at low risk of arteriosclerosis who presented with disorders on the left side including gaze-evoked nystagmus, paralysis of the ...

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Renal transplantation in antineutrophil cytoplasmic antibody-associated vasculitis.

PURPOSE OF REVIEW This review aims to provide a state-of-the-art perspective on the role of kidney transplantation in cases of end-stage kidney disease due to antineutrophil cytoplasmic antibody (ANCA) vasculitis. We focus on patient and graft survival in recent years, timing of transplant, impact of ANCA status, and relapse of vasculitis in the allograft. RECENT FINDINGS Graft and patient ou...

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ژورنال

عنوان ژورنال: Journal of Clinical Investigation

سال: 2002

ISSN: 0021-9738

DOI: 10.1172/jci200216699